SCHEMBL645184

SCHEMBL645184

COC(=O)Cc1ccc(C=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 2/20 0.59
CYP4A11 Q02928 2/20 0.59
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 6/20 0.53
GAA P10253 1/20 0.49
GFER P55789 1/20 0.49
HSP90AB1 P08238 1/20 0.48
SMN1; SMN2 Q16637 4/20 0.45
NPC1 O15118 4/20 0.45
RAB9A P51151 4/20 0.45
MAPT P10636 2/20 0.45
TP53 P04637 2/20 0.45
LMNA P02545 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP2A6 P11509 1/20 0.45
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7214877 0.95 CYP4F2 (0.54) CYP4F2CYP4A11KMT2AALDH1A1GAA
SCHEMBL4113212 0.85 CYP4F2 (0.76) CYP4F2CYP4A11KMT2AALDH1A1GAA
SCHEMBL14404459 0.85 SMN1; SMN2 (0.69) KMT2AALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL1803272 0.83 CYP4Z1 (0.56) CYP4F2CYP4A11KMT2AALDH1A1SMN1; SMN2
SCHEMBL6257338 0.83 CYP4F2 (0.58) CYP4F2CYP4A11KMT2AALDH1A1GAA
SCHEMBL10456252 0.82 CYP4F2 (0.53) CYP4F2CYP4A11KMT2AALDH1A1GAA
SCHEMBL10456253 0.82 CYP4F2 (0.53) CYP4F2CYP4A11KMT2AALDH1A1GAA
SCHEMBL697461 0.81 CYP4F2 (0.50) CYP4F2CYP4A11KMT2AALDH1A1MAPT
SCHEMBL14606148 0.80 F3 (0.56) CYP4F2CYP4A11ALDH1A1GAAGFER
SCHEMBL8784633 0.80 CYP4F2 (0.54) CYP4F2CYP4A11KMT2AALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES UNIV YALE (US) 2026-04-30 US disclosed
EP-4721737-A1 USE OF PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND HAVING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE FOR TREATING ANEMIA-RELATED DISEASES Scinnohub Pharmaceutical Co., Ltd. (CN) 2026-04-08 EP disclosed
EP-4680336-A1 AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF Ventus Therapeutics U.S., Inc. (US) 2026-01-21 EP disclosed
US-20260007684-A1 AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF VENTUS THERAPEUTICS U S INC (US) 2026-01-08 US disclosed
CN-120058611-A 1-Aryl-5-pyrazolone compound, and pharmaceutical composition and application thereof 中国药科大学 2025-05-30 CN disclosed
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE SCINNOHUB PHARMACEUTICAL CO., LTD. (CN) 2025-05-08 US disclosed
US-20250145590-A1 UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 US disclosed
WO-2025096539-A1 UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 WO disclosed
US-20250093270-A1 Method for Detecting Enzyme Activity and Fluorescent Probe Used in Said Method THE UNIVERSITY OF TOKYO (JP) 2025-03-20 US disclosed
EP-4488379-A1 METHOD FOR DETECTING ENZYME ACTIVITY AND FLUORESCENT PROBE USED IN SAID METHOD The University of Tokyo (JP) 2025-01-08 EP disclosed
WO-2005058834-A2 QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE WYETH (US) 2005-06-30 WO disclosed
US-20050131014-A1 Quinolines useful in treating cardiovascular disease WYETH (US) 2005-06-16 US disclosed
WO-2005004796-A2 SULFONYLAMINO PHENYLACETAMIDE DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2005-01-20 WO disclosed
US-20040254156-A1 Sulfonylamino phenylacetamide derivatives and methods of their use CALIXA THERAPEUTICS, INC. 2004-12-16 US disclosed
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 EP disclosed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 WO disclosed
WO-1995005376-A1 SUBSTITUTED 2(5H)FURANONE, 2(5H)THIOPHENONE AND 2(5H)PYRROLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1995-02-23 WO disclosed
US-4560749-A ANTIBIOTICS, BACTERICIDES ELI LILLY AND COMPANY (US) 1985-12-24 US disclosed
US-4521598-A 3-Azidocephalosporins ELI LILLY AND COMPANY (US) 1985-06-04 US disclosed
EP-0136177-A2 3-Azidocephalosporins as intermediates and novel antibacterial agents ELI LILLY AND COMPANY (US) 1985-04-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145635-A1 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE BCL9, USP9X, BCL9L CYP4F2 4431/4885CYP4A11 3759/4885KMT2A 646/4885
US-20250093270-A1 Method for Detecting Enzyme Activity and Fluorescent Probe Used in Said Method ACHE, BCHE, SCLY CYP4F2 931/4885CYP4A11 2119/4885KMT2A 2133/4885
US-20040254156-A1 Sulfonylamino phenylacetamide derivatives and methods of their use CYP2E1, CYP2D6, CYP3A43 CYP4F2 44/4885CYP4A11 49/4885KMT2A 1728/4885
US-20250145590-A1 UBIQUITIN SPECIFIC PROCESSING PROTEASE 1 (USP1) COMPOUNDS USP1, UBA1, SUMO1 CYP4F2 3371/4885CYP4A11 846/4885KMT2A 1095/4885
US-20050131014-A1 Quinolines useful in treating cardiovascular disease NR1H2, NR1H3, SREBF1 CYP4F2 246/4885CYP4A11 113/4885KMT2A 1330/4885
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, VHL, ADRM1 CYP4F2 3705/4885CYP4A11 4354/4885KMT2A 2541/4885
US-20260007684-A1 AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF NOD1, NLRP3, NOD2 CYP4F2 1480/4885CYP4A11 328/4885KMT2A 4575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.