Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 5/20 | 0.32 |
| ▸ | PPARA | Q07869 | 4/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216023 | 0.91 | L3MBTL1 (0.34) | RARBHTTMEN1KMT2APPARD | |
| SCHEMBL7222573 | 0.90 | POLB (0.38) | RARBMEN1KMT2APPARDKDM4E | |
| SCHEMBL7222487 | 0.90 | RARB (0.38) | RARBPPARDPPARAPPARGKDM4E | |
| SCHEMBL7215993 | 0.87 | KMT2A (0.39) | RARBKMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7216344 | 0.84 | THRB (0.34) | MEN1KMT2A | |
| SCHEMBL7218340 | 0.83 | LTA4H (0.40) | HTTKMT2ALMNAL3MBTL1 | |
| SCHEMBL7216783 | 0.82 | PPARD (0.35) | RARBMEN1KMT2APPARDPPARG | |
| SCHEMBL7247416 | 0.82 | RARB (0.46) | RARBKDM4ERARALMNA | |
| SCHEMBL7218217 | 0.82 | S1PR1 (0.36) | MEN1KMT2APPARDPPARAPPARG | |
| SCHEMBL7215961 | 0.81 | HRH3 (0.39) | RARBKMT2ARXRAPPARGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627651-B1 | Exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group and inhibitors of HIV (human | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| EP-1182195-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |