Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL15689579 | 0.88 | PSMB5 (0.57) | LTA4HCA2CA1ACEPSMB5 | |
| SCHEMBL7216961 | 0.86 | PSMB5 (0.53) | LTA4HCA2CA1ACEPSMB5 | |
| Leucine SCHEMBL15689447 | 0.82 | L3MBTL1 (0.49) | LTA4HCA2CA1ACEPTPN1 | |
| Leucine SCHEMBL15689461 | 0.80 | NPC1 (0.60) | LTA4HCA2CA1PSMB5PTPN1 | |
| Leucine SCHEMBL7211002 | 0.78 | LTA4H (0.49) | LTA4HACEL3MBTL1MMP2MMP7 | |
| Leucine SCHEMBL1041561 | 0.78 | PSMB5 (0.63) | LTA4HCA2CA1PSMB5 | |
| Leucine SCHEMBL21955431 | 0.78 | PSMB5 (0.63) | LTA4HCA2CA1PSMB5 | |
| D-Leucine SCHEMBL2338392 | 0.78 | PSMB5 (0.63) | LTA4HCA2CA1PSMB5 | |
| Leucine SCHEMBL2336540 | 0.78 | PSMB5 (0.63) | LTA4HCA2CA1PSMB5 | |
| Leucine SCHEMBL15689496 | 0.78 | KMO (0.51) | CA2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617317-B1 | Reducing the rate of degradation of proteins in an animal | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-09 | — | — | US | claimed |
| US-6465433-B1 | SUCH AS N-(2-PYRIDINE)CARBONYL-L-PHENYLALANINE-L-LEUCINE BORONIC ACID; PROTEASOME INHIBITORS; REDUCING RATE OF MUSCLE PROTEIN DEGRADATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-10-15 | — | — | US | claimed |
| US-6083903-A | REDUCE RATE OF DEGRADATION OF PROTEINS IN ANIMAL | LEUKOSITE, INC. (US) | 2000-07-04 | — | — | US | claimed |