Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216729 | 0.99 | ACHE (0.48) | ACHECYP1A2CYP3A4SLC6A3LTA4H | |
| SCHEMBL7220239 | 0.87 | ACHE (0.52) | ACHECYP3A4SLC6A3MAPK14MAPK13 | |
| SCHEMBL7216865 | 0.85 | ACHE (0.43) | ACHECYP1A2CYP3A4SLC6A3LTA4H | |
| SCHEMBL7220974 | 0.75 | DPP4 (0.38) | SLC6A3LTA4HMAPK14MAPK13MAPK12 | |
| SCHEMBL7216927 | 0.73 | KDM4E (0.49) | ACHECYP3A4SLC6A3MAPK14MAPK13 | |
| SCHEMBL7221098 | 0.71 | TAAR1 (0.39) | CYP3A4SLC6A3MAPK14MAPK13MAPK12 | |
| SCHEMBL7216749 | 0.71 | LOXL2 (0.38) | SLC6A3LTA4HMAPK14 | |
| SCHEMBL7220444 | 0.71 | PRCP (0.41) | SLC6A3NPSR1 | |
| SCHEMBL7214547 | 0.69 | MAOB (0.39) | CYP3A4SLC6A3LMNANPSR1 | |
| SCHEMBL7215286 | 0.69 | KMT2A (0.46) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |