Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | EIF4E | P06730 | 4/20 | 0.49 |
| ▸ | SDHB | P21912 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | CDC25C | P30307 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215544 | 0.92 | ALDH1A1 (0.67) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7221406 | 0.87 | MAPT (0.59) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7221341 | 0.86 | KDM4E (0.74) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7217144 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL7215074 | 0.84 | CYP19A1 (0.50) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7220984 | 0.84 | RAB9A (0.55) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27538601 | 0.82 | SDHB (0.57) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7215657 | 0.81 | CDC25A (0.60) | KDM4EKMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL28507787 | 0.80 | CA12 (0.59) | SDHB | |
| SCHEMBL29917375 | 0.80 | CA12 (0.59) | SDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545009-B1 | Imidazole, oxazole and thiazole derivatives for regulation of peroxisome proliferator-activated receptor function; improving insulin resistance, treating impaired glucose tolerance and obesity, enhancing insulin sensitivity, etc. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| EP-1092711-A1 | RETINOID-ASSOCIATED RECEPTOR REGULATORS | Takeda Chemical Industries, Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |