SCHEMBL7218376

SCHEMBL7218376

O=C1C=CC(=O)N1Cc1ccc(Cl)cc1

nearest known ligand 0.82

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.82
FAAH O00519 2/20 0.82
GSK3A P49840 2/20 0.65
GSK3B P49841 2/20 0.65
PTGS1 P23219 2/20 0.60
PTGS2 P35354 2/20 0.60
CES2 O00748 1/20 0.53
BCHE P06276 1/20 0.53
CES1 P23141 1/20 0.53
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
TP53 P04637 1/20 0.46
MAPT P10636 1/20 0.44
THRB P10828 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
APAF1 O14727 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL146412 0.91 MGLL (1.00) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL8950019 0.84 MGLL (0.86) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL21215698 0.84 MGLL (0.86) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL14677902 0.81 MGLL (0.66) MGLLFAAHGSK3AGSK3BTP53
SCHEMBL9610843 0.80 MGLL (1.00) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL4804503 0.80 MGLL (0.78) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL15704375 0.80 MGLL (0.78) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL15657951 0.80 MGLL (0.78) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL7871290 0.80 MGLL (0.78) MGLLFAAHGSK3AGSK3BPTGS1
SCHEMBL19555152 0.80 MGLL (0.78) MGLLFAAHGSK3AGSK3BPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024173715-A1 ANTIFUNGAL COMPOSITIONS AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-08-22 WO claimed
WO-2024173715-A1 ANTIFUNGAL COMPOSITIONS AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-08-22 WO disclosed
US-11840514-B2 Catalysts and methods for enantioselective conjugate addition of amines to unsaturated electrophiles NORTHWESTERN UNIVERSITY (US) 2023-12-12 US disclosed
CN-112028808-B Preparation method of N-substituted-3-methyl mercapto-4-morpholinyl maleimide compound 温州医科大学 2023-10-13 CN disclosed
US-20210002221-A1 CATALYSTS AND METHODS FOR ENANTIOSELECIVE CONJUGATE ADDITION OF AMINES TO UNSATURATED ELECTROPHILES NORTHWESTERN UNIVERSITY 2021-01-07 US disclosed
CN-112028808-A Preparation method of N-substituted-3-methylmercapto-4-morpholinyl maleimide compound 温州医科大学 2020-12-04 CN disclosed
CN-111732606-A Synthesis method of diethyl S- (N-substituted-4-morpholinyl-2, 5-dioxo-2, 5-dihydro-1-pyrrole) dithiophosphate 温州医科大学 2020-10-02 CN disclosed
US-10781172-B2 Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles NORTHWESTERN UNIVERSITY (US) 2020-09-22 US disclosed
CN-111440108-A Synthetic method of N-substituted-3-benzylmercapto-4-morpholinyl maleimide compound 温州医科大学 2020-07-24 CN disclosed
CN-107162950-A N substitution maleimide compounds and its preparation based on pharmaceutical intermediate are studied with antibacterial activity 浙江工业大学 2017-09-15 CN disclosed
US-20130025495-A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER AND USES THEREOF ISP INVESTMENTS INC. (US) 2013-01-31 US disclosed
US-20130025495-A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER AND USES THEREOF ISP INVESTMENTS INC. (US) 2013-01-31 US disclosed
US-20130025495-A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER AND USES THEREOF ISP INVESTMENTS INC. (US) 2013-01-31 US disclosed
CN-102352122-A Pigment-resin composition, resin composition for ink-jet type color filter, the ink-jet type color filter and liquid crystal display device JSR CORP 2012-02-15 CN disclosed
CN-102286218-A Pigment resin composition, resin composition for ink jet mode color filter, color filter and liquid crystal display device 2011-12-21 CN disclosed
CN-101139475-A Pigment resin composition, resin composition for ink-jet color filter, and liquid crystal display device JSRKABUSHIKI KAISHA (JP) 2008-03-12 CN disclosed
US-6627364-B2 Contains (A) a colorant, (B) a binder resin and (C) a solvent having a boiling point of 245 degrees C. or more at normal pressure. SEIKO EPSON CORPORATION (JP) 2003-09-30 US disclosed
US-20020128351-A1 Ink jet color filter resin composition, color filter and color filter production process SEIKO EPSON CORPORATION (JP) 2002-09-12 US disclosed
EP-1048700-A1 Ink jet color filter resin composition, color filter production process SEIKO EPSON CORPORATION (JP) 2000-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130025495-A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER AND USES THEREOF MEP1A, MACF1, CYP1B1 MGLL 1404/4885FAAH 2247/4885GSK3A 4587/4885
US-11840514-B2 Catalysts and methods for enantioselective conjugate addition of amines to unsaturated electrophiles AADAC, COASY, PAICS MGLL 1314/4885FAAH 469/4885GSK3A 3240/4885
US-10781172-B2 Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles AADAC, COASY, PAICS MGLL 1253/4885FAAH 503/4885GSK3A 3147/4885
US-20210002221-A1 CATALYSTS AND METHODS FOR ENANTIOSELECIVE CONJUGATE ADDITION OF AMINES TO UNSATURATED ELECTROPHILES COASY, AADAC, AOC1 MGLL 1655/4885FAAH 583/4885GSK3A 3059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.