Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | MITF | O75030 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203373 | 0.90 | PBRM1 (0.88) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL29492473 | 0.90 | PBRM1 (0.88) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL9097509 | 0.90 | PBRM1 (0.88) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL9973084 | 0.87 | PBRM1 (0.69) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL29037240 | 0.86 | PBRM1 (0.81) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL17744847 | 0.86 | PBRM1 (0.81) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL127545 | 0.86 | PBRM1 (0.81) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL5114913 | 0.86 | PBRM1 (0.81) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL5832368 | 0.86 | PBRM1 (0.81) | PBRM1LMNANPC1MITFPOLB | |
| SCHEMBL8549972 | 0.86 | LMNA (0.73) | PBRM1LMNANPC1MITFPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073314-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-03-16 | — | — | US | disclosed |
| US-6623786-B2 | Method for hydrogel surface treatment | NOVARTIS AG (CH) | 2003-09-23 | — | — | US | disclosed |
| US-20010024697-A1 | Method for hydrogel surface treatment and article formed therefrom | BARON RICHARD CARLTON (US) | 2001-09-27 | — | — | US | disclosed |
| EP-1023617-A1 | METHOD FOR HYDROGEL SURFACE TREATMENT AND ARTICLE FORMED THEREFROM | Novartis AG (CH) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999015917-A1 | METHOD FOR HYDROGEL SURFACE TREATMENT AND ARTICLE FORMED THEREFROM | NOVARTIS AG (CH) | 1999-04-01 | — | — | WO | disclosed |
| US-RE29032-E | ANTIINFLAMMATORY AGENTS | RIKER LABORATORIES, INC. (US) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073314-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK5 | PBRM1 4429/4885LMNA 1126/4885NPC1 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.