Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459309 | 0.81 | AURKA (1.00) | AURKA | |
| SCHEMBL13461148 | 0.79 | ERBB2 (0.70) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL16011809 | 0.78 | ALK (0.54) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL31240940 | 0.78 | AURKA (0.68) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL675631 | 0.78 | AURKA (0.68) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL23967951 | 0.78 | ERBB2 (0.65) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL17559198 | 0.78 | ALK (0.54) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL31662764 | 0.76 | AURKA (0.49) | AURKAALKERBB2UTS2RPTK6 | |
| SCHEMBL3473013 | 0.76 | LIMK1 (0.59) | ALKERBB2EGFRCA5AMAPT | |
| SCHEMBL30159366 | 0.76 | LIMK1 (0.59) | ALKERBB2EGFRCA5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670371-B2 | Antagonists of Corticotropin-Releasing Factor | NEUROGEN CORPORATION | 2003-12-30 | — | — | US | disclosed |
| US-20020111490-A1 | Certain pyrrolopyridine derivatives: novel CRF1 specific ligands | NEUROGEN CORPORATION (US) | 2002-08-15 | — | — | US | disclosed |
| US-6355651-B1 | AMINE SUBSTITUTED HETEROCYCLIC COMPOUNDS | NEUROGEN CORPORATION | 2002-03-12 | — | — | US | disclosed |
| US-6133282-A | Certain pyrrolopyridine derivatives; novel CRF1 specific ligands | NEUROGEN CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1998045295-A1 | CERTAIN PYRROLOPYRIDINE DERIVATIVES; NOVEL CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111490-A1 | Certain pyrrolopyridine derivatives: novel CRF1 specific ligands | CRHR1, CRH, CRHR2 | AURKA 3950/4885ALK 737/4885ERBB2 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.