Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215883 | 0.85 | ADAM17 (0.36) | MAPTKMT2ATP53 | |
| SCHEMBL7213677 | 0.84 | GRM2 (0.38) | LMNAMEN1KMT2A | |
| SCHEMBL7220659 | 0.81 | NPSR1 (0.44) | MMP2MMP9MMP8MMP13TLR9 | |
| SCHEMBL2520593 | 0.79 | ALDH1A1 (0.39) | ELANECYP3A4TLR9MEN1KMT2A | |
| SCHEMBL11256573 | 0.71 | ELANE (0.40) | ELANECYP3A4MMP2MMP9MMP8 | |
| SCHEMBL29195204 | 0.71 | ELANE (0.46) | ELANECYP3A4MMP2MMP9MMP8 | |
| SCHEMBL576624 | 0.70 | ELANE (0.39) | ELANECYP3A4PARP1MMP2MMP9 | |
| SCHEMBL9413704 | 0.68 | ELANE (0.37) | ELANECYP3A4PARP1CTSGPRTN3 | |
| SCHEMBL7097777 | 0.67 | ALDH1A1 (0.60) | ELANECYP3A4MMP2MMP9MMP8 | |
| SCHEMBL15972776 | 0.67 | ALDH1A1 (0.60) | ELANECYP3A4MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6504046-B1 | Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2003-01-07 | — | — | US | disclosed |
| EP-1092705-A1 | PROCESS FOR THE PREPARATION OF AMIDES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-4680284-A | RENNIN INHIBITORS, HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |