Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272506 | 1.00 | ELANE (0.40) | ELANEBACE1CTSGPRTN3TSHR | |
| SCHEMBL7220662 | 0.83 | NPSR1 (0.41) | ALDH1A1MMP2MMP9MMP8MMP13 | |
| SCHEMBL11268643 | 0.82 | ALDH1A1 (0.40) | ELANEBACE1PIK3CDALDH1A1GAA | |
| SCHEMBL19239774 | 0.81 | RAB9A (0.36) | ALDH1A1GAA | |
| SCHEMBL508332 | 0.80 | ELANE (0.36) | ELANEBACE1CTSGPRTN3PIK3CD | |
| SCHEMBL7662936 | 0.69 | MMP2 (0.37) | BACE1ALDH1A1MMP2MMP9CYP1A2 | |
| SCHEMBL6827479 | 0.67 | BACE1 (0.43) | BACE1MMP2MMP9CYP2C9 | |
| SCHEMBL16174713 | 0.67 | ELANE (0.44) | ELANECTSGPRTN3ALDH1A1GAA | |
| SCHEMBL16174913 | 0.66 | ELANE (0.51) | ELANEBACE1CTSGPRTN3ALDH1A1 | |
| SCHEMBL11256573 | 0.66 | ELANE (0.40) | ELANEBACE1CTSGPRTN3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6504046-B1 | Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2003-01-07 | — | — | US | disclosed |
| EP-1092705-A1 | PROCESS FOR THE PREPARATION OF AMIDES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-4680284-A | RENNIN INHIBITORS, HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |