Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4835712 | 0.82 | GABRA1 (0.50) | KMT2AALDH1A1MEN1TP53HPGD | |
| SCHEMBL7218429 | 0.76 | NQO2 (0.40) | NQO2MTNR1AMTNR1BKMT2AALDH1A1 | |
| SCHEMBL3837986 | 0.71 | KMT2A (0.41) | KMT2AALDH1A1MEN1TP53HPGD | |
| SCHEMBL3842038 | 0.71 | GABRA1 (0.39) | KMT2AALDH1A1MEN1TP53HPGD | |
| SCHEMBL3839419 | 0.70 | MEN1 (0.37) | KMT2AALDH1A1MEN1TP53HPGD | |
| SCHEMBL3837988 | 0.69 | HSD17B10 (0.39) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL3250627 | 0.67 | MAPT (0.46) | NQO2KMT2AALDH1A1MEN1 | |
| SCHEMBL8556198 | 0.65 | MEN1 (0.39) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL810412 | 0.65 | ALDH1A1 (0.43) | KMT2AALDH1A1MEN1HPGDL3MBTL1 | |
| SCHEMBL28857890 | 0.65 | RAB9A (0.51) | KMT2AALDH1A1MEN1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362034-A1 | QUINOLINE, ISOQUINOLINE AND PHTHALAZINE DERIVATIVES AS ANTAGONISTS OF THE GONADOTROPIN-RELEASING HORMONE | Schering Aktiengesellschaft (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066437-A1 | QUINOLINE, ISOQUINOLINE AND PHTHALAZINE DERIVATIVES AS ANTAGONISTS OF THE GONADOTROPIN-RELEASING HORMONE | ZENTARIS GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |