Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.49 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18845562 | 0.82 | HCRTR1 (0.52) | TMEM97SIGMAR1PREPAADATMEN1 | |
| SCHEMBL1061153 | 0.78 | CPT2 (0.54) | TMEM97SIGMAR1PREPAADAT | |
| SCHEMBL4033512 | 0.78 | TMEM97 (0.68) | TMEM97SIGMAR1PREPFKBP1A | |
| SCHEMBL10173023 | 0.78 | HCRTR1 (0.47) | TMEM97SIGMAR1PREPAADATMEN1 | |
| SCHEMBL29176554 | 0.78 | ALDH1A1 (0.56) | MEN1ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL29176551 | 0.78 | ALDH1A1 (0.56) | MEN1ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL5717223 | 0.78 | TMEM97 (0.52) | TMEM97SIGMAR1PREPAADATFKBP1A | |
| Water SCHEMBL27700641 | 0.77 | TMEM97 (0.67) | TMEM97SIGMAR1PREPFKBP1A | |
| SCHEMBL27207832 | 0.77 | PKM (0.52) | RYR2MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL27230216 | 0.77 | PKM (0.52) | RYR2MEN1ALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6544987-B2 | Pyrrolidine or piperidine sulfonyl compounds; stimulate neurite outgrowth in nerve cells leading to nerve regeneration for treatment of hair loss, memory loss or vision disorders | PFIZER INC. | 2003-04-08 | — | — | US | disclosed |
| EP-1237869-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2002-09-11 | — | — | EP | disclosed |
| US-20020061881-A1 | Compounds, compositions, and methods for stimulating neuronal growth and elongation | AGOURON PHARMACEUTICALS, INC. | 2002-05-23 | — | — | US | disclosed |
| WO-2001040185-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061881-A1 | Compounds, compositions, and methods for stimulating neuronal growth and elongation | NGF, GAP43, BDNF | TMEM97 4169/4885SIGMAR1 4103/4885RYR2 4587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.