SCHEMBL7220392

SCHEMBL7220392

COc1nc(C)cc(C=O)c1[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
MAPT P10636 2/20 0.45
KDM4E B2RXH2 1/20 0.45
CYP3A4 P08684 1/20 0.45
ALOX15 P16050 1/20 0.45
PRKDC P78527 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ERN1 O75460 3/20 0.41
KMT2A Q03164 3/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 2/20 0.36
HTT P42858 1/20 0.36
CYP2C9 P11712 1/20 0.35
AGTR1 P30556 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
TSHR P16473 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8808836 0.80 LMNA (0.46) ALDH1A1MAPTKDM4ECYP3A4ALOX15
SCHEMBL18031283 0.79 ALDH1A1 (0.44) ALDH1A1MAPTKDM4EKMT2ALMNA
SCHEMBL30622635 0.79 LMNA (0.40) ALDH1A1MAPTCYP3A4KMT2ALMNA
SCHEMBL8808441 0.76 ALDH1A1 (0.38) ALDH1A1MAPTALOX15KMT2ALMNA
SCHEMBL7220292 0.75 ALDH1A1 (0.42) ALDH1A1MAPTKMT2ALMNAHTT
SCHEMBL7372433 0.74 MEN1 (0.46) ALDH1A1MAPTKDM4ECYP3A4ALOX15
SCHEMBL29125246 0.73 ALDH1A1 (0.44) ALDH1A1MAPTKDM4ECYP3A4ALOX15
SCHEMBL9121830 0.71 ALDH1A1 (0.45) ALDH1A1MAPTKDM4EKMT2ALMNA
SCHEMBL7015986 0.71 MAPT (0.45) ALDH1A1MAPTKDM4EALOX15KMT2A
SCHEMBL4224151 0.69 ALDH1A1 (0.54) ALDH1A1MAPTKDM4ECYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610692-B1 Anticoagulants MERCK & CO., INC. 2003-08-26 US disclosed
US-6376499-B1 PIPERAZINE-AMIDE COMPOUND WITH ANTICOAGULANT ACTIVITY MERCK & CO., INC. 2002-04-23 US disclosed
EP-1124822-A4 THROMBIN INHIBITORS MERCK & CO INC (US) 2002-04-03 EP disclosed
EP-1082324-A4 IMIDAZOPYRIDINE THROMBIN INHIBITORS MERCK & CO INC (US) 2002-01-02 EP disclosed
EP-1017383-A4 THROMBIN INHIBITORS MERCK & CO INC (US) 2001-11-28 EP disclosed
EP-1124823-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 2001-08-22 EP disclosed
EP-1124822-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 2001-08-22 EP disclosed
EP-1082324-A1 IMIDAZOPYRIDINE THROMBIN INHIBITORS Merck & Co., Inc. (US) 2001-03-14 EP disclosed
US-6093717-A A SERINE PROTEASE INHIBITOR PREVENTING CORONARY ARTERY DISEASE AND INHIBITING THROMBUS FORMATION IN BLOOD MERCK & CO., INC. (US) 2000-07-25 US disclosed
EP-1017383-A1 THROMBIN INHIBITORS Merck & Co., Inc. (US) 2000-07-12 EP disclosed
US-6087373-A A SERINE PROTEASE INHIBITOR FOR PREVENTING OR TREATING UNSTABLE ANGINA, REFRACTORY ANGINA, MYOCARDIAL INFARCTION, TRANSIENT ISCHEMIC ATTACKS, ATRIAL FIBRILLATION, THROMBOTIC STROKE, EMBOLIC STROKE, DEEP VEIN THROMBOSIS MERCK & CO., INC. (US) 2000-07-11 US disclosed
WO-2000026210-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO disclosed
WO-2000026211-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO disclosed
WO-1999061442-A1 IMIDAZOPYRIDINE THROMBIN INHIBITORS MERCK & CO., INC. (US) 1999-12-02 WO disclosed
WO-1999015169-A1 THROMBIN INHIBITORS MERCK & CO., INC. (US) 1999-04-01 WO disclosed