Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168561 | 0.78 | CASP3 (0.41) | MAOBMAOACASP1CASP7MMP2 | |
| SCHEMBL14879995 | 0.77 | NTMT1 (0.47) | KMT2A | |
| SCHEMBL5400405 | 0.76 | MAOB (0.55) | MAOBMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL5400401 | 0.76 | MAOB (0.55) | MAOBMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL7521630 | 0.75 | ANPEP (0.69) | TSHRALDH1A1FNTAFNTBANPEP | |
| SCHEMBL7521626 | 0.75 | ANPEP (0.69) | TSHRALDH1A1FNTAFNTBANPEP | |
| SCHEMBL6930389 | 0.74 | MAOB (0.53) | MAOBMAOAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL16401469 | 0.72 | MAOB (0.49) | MAOBMAOAALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7402074 | 0.71 | PTGER4 (0.44) | MAOBKMT2ANPC1RAB9A | |
| SCHEMBL7402070 | 0.71 | PTGER4 (0.44) | MAOBKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589949-B1 | Methods for production thereof and use thereof in the production of medicaments for the prophylaxis and/or treatment of diseases of the central nervous system, in particular, cognitive disorders, such as Alzheimer's disease and other | BAYER AKTIENGESELLSCHAFT (DE) | 2003-07-08 | — | — | US | disclosed |