Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568255 | 0.80 | LMNA (0.46) | OPRL1KMT2ALMNAMEN1NPSR1 | |
| SCHEMBL6568258 | 0.80 | LMNA (0.46) | OPRL1KMT2ALMNAMEN1NPSR1 | |
| SCHEMBL6568332 | 0.73 | ITGA4 (0.47) | — | |
| SCHEMBL6569671 | 0.73 | OPRL1 (0.44) | OPRL1 | |
| SCHEMBL10420330 | 0.73 | OPRL1 (0.44) | OPRL1 | |
| SCHEMBL5651677 | 0.72 | CYP2D6 (0.47) | SMN1; SMN2OPRL1ALDH1A1 | |
| SCHEMBL10510512 | 0.72 | CYP2D6 (0.47) | SMN1; SMN2OPRL1ALDH1A1 | |
| SCHEMBL13534726 | 0.72 | CYP2D6 (0.47) | SMN1; SMN2OPRL1ALDH1A1 | |
| SCHEMBL6075390 | 0.72 | CYP2D6 (0.47) | SMN1; SMN2OPRL1ALDH1A1 | |
| SCHEMBL13534719 | 0.68 | OPRL1 (0.42) | OPRL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545160-B2 | Alpha-aminoacetic acid derivatives bind alpha 4 beta 7 integrin, useful for treatment of inflammatory diseases in mammalian patient, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, rheumatoid arthritis | ELAN PHARMACEUTICALS, INC. | 2003-04-08 | — | — | US | disclosed |