Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.35 |
| ▸ | USP7 | Q93009 | 2/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 4/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224358 | 0.86 | SLC6A3 (0.36) | CHRNA7HTR3ASLC6A3SLC6A4CHRNA1 | |
| SCHEMBL7223174 | 0.85 | CHRNA7 (0.33) | CHRNA7HTR3ACHRNB4CHRNA3HTR3E | |
| SCHEMBL7231186 | 0.84 | CHRNA7 (0.33) | CHRNA7HTR3ATAS1R3TAS1R1SLC6A3 | |
| SCHEMBL7223431 | 0.84 | HTR3E (0.33) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7224323 | 0.83 | MEN1 (0.38) | F10 | |
| SCHEMBL7225927 | 0.83 | CHRNA7 (0.35) | CHRNA7HTR3ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7240585 | 0.82 | HSD17B10 (0.35) | CHRNA7HTR3ACHRNB4CHRNA3HTR3E | |
| SCHEMBL7230214 | 0.82 | SIRT1 (0.36) | CHRNA7HTR3ACHRNB4CHRNA3HTR3E | |
| SCHEMBL7226168 | 0.82 | HSD17B1 (0.37) | USP7SLC6A3SLC6A4F10 | |
| SCHEMBL7234021 | 0.82 | SLC6A3 (0.39) | CHRNA7USP7HTR3ASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |