Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.32 |
| ▸ | HTR3B | O95264 | 5/20 | 0.32 |
| ▸ | HTR3A | P46098 | 5/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223174 | 0.88 | CHRNA7 (0.33) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223538 | 0.88 | ALDH1A1 (0.35) | MAPT | |
| SCHEMBL7231186 | 0.87 | CHRNA7 (0.33) | CHRNA7TAS1R3TAS1R1HTR3EHTR3B | |
| SCHEMBL7223431 | 0.87 | HTR3E (0.33) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223906 | 0.86 | LMNA (0.36) | CHRNA7LMNAMAPTNPSR1DDB1 | |
| SCHEMBL7232388 | 0.85 | PRKCB (0.32) | KDM4ETSHRHSD17B10 | |
| SCHEMBL7240585 | 0.85 | HSD17B10 (0.35) | CHRNA7MAPTHTR3EHTR3BHTR3A | |
| SCHEMBL7230214 | 0.85 | SIRT1 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232807 | 0.84 | CHRNA7 (0.41) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231965 | 0.84 | CHRNA7 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |