Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.32 |
| ▸ | HTR3B | O95264 | 3/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.32 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225045 | 0.89 | SLC6A3 (0.41) | SLC6A2SLC6A4SLC6A3ADRB1ADRB3 | |
| SCHEMBL7226014 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3POLBCHRNA7 | |
| SCHEMBL7231868 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7231813 | 0.89 | CHRNA7 (0.34) | SLC6A2SLC6A4SLC6A3ADRB1ADRB3 | |
| SCHEMBL7225381 | 0.89 | HTR3E (0.37) | SLC6A2SLC6A4SLC6A3HTR3EHTR3B | |
| SCHEMBL7233323 | 0.88 | ESR1 (0.37) | SLC6A2SLC6A4SLC6A3ESR1ESRRG | |
| SCHEMBL7230406 | 0.87 | PARP14 (0.38) | NPC1 | |
| SCHEMBL7232389 | 0.87 | NPC1 (0.36) | SLC6A2SLC6A4SLC6A3HTR3EHTR3B | |
| SCHEMBL7225098 | 0.87 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ESRRGHTR3A | |
| SCHEMBL7230191 | 0.87 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |