Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.37 |
| ▸ | HTR3B | O95264 | 5/20 | 0.37 |
| ▸ | HTR3A | P46098 | 5/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233323 | 0.90 | ESR1 (0.37) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7231264 | 0.89 | CYP1A2 (0.32) | CHRNA7SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7232095 | 0.89 | CHRNA7 (0.34) | CHRNA7SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7229845 | 0.89 | SLC6A3 (0.42) | MMP13SLC6A4SLC6A2SLC6A3NPC1 | |
| SCHEMBL7225066 | 0.89 | SLC6A4 (0.41) | CHRNA7SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7225149 | 0.89 | HTR4 (0.37) | SLC6A4SLC6A2SLC6A3NPC1 | |
| SCHEMBL7223531 | 0.89 | CHRNB4 (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7225557 | 0.88 | SLC8A1 (0.37) | CHRNA7 | |
| SCHEMBL7226014 | 0.88 | SLC6A2 (0.41) | CHRNA7SLC6A4SLC6A2SLC6A3NPC1 | |
| SCHEMBL7225045 | 0.88 | SLC6A3 (0.41) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |