Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231868 | 0.90 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7225149 | 0.90 | HTR4 (0.37) | SLC6A2SLC6A4SLC6A3HTR4ALDH1A1 | |
| SCHEMBL7223531 | 0.89 | CHRNB4 (0.40) | SLC6A2SLC6A4SLC6A3NPC1POLB | |
| SCHEMBL7232389 | 0.89 | NPC1 (0.36) | SLC6A2SLC6A4SLC6A3GRM5ALDH1A1 | |
| SCHEMBL7225045 | 0.88 | SLC6A3 (0.41) | SLC6A2SLC6A4SLC6A3GRM5 | |
| SCHEMBL7231813 | 0.88 | CHRNA7 (0.34) | SLC6A2SLC6A4SLC6A3CHRNA7 | |
| SCHEMBL7225381 | 0.88 | HTR3E (0.37) | SLC6A2SLC6A4SLC6A3NPC1CHRNA7 | |
| SCHEMBL7225732 | 0.87 | SMN1; SMN2 (0.36) | MTNR1AMTNR1BALDH1A1NPC1RAB9A | |
| SCHEMBL7230406 | 0.87 | PARP14 (0.38) | NPC1OPRM1OPRD1 | |
| SCHEMBL7234424 | 0.86 | F2 (0.35) | SLC6A2SLC6A4SLC6A3ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |