Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217250 | 0.88 | L3MBTL1 (0.49) | P2RX4P2RX3FOLH1MAPTKDM4E | |
| SCHEMBL7218561 | 0.84 | MEN1 (0.47) | ATMMAPTRXFP1KDM4EPTGER4 | |
| SCHEMBL7224007 | 0.82 | EGFR (0.50) | HDAC6ATMMAPTKDM4EPTGER4 | |
| SCHEMBL11840599 | 0.77 | P2RX4 (0.58) | P2RX4MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7217228 | 0.76 | P2RX4 (0.50) | P2RX4HDAC1HDAC6HDAC11HDAC8 | |
| SCHEMBL11843160 | 0.76 | PCSK9 (0.54) | P2RX4MAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL18271771 | 0.74 | HDAC6 (0.66) | DRD2TBXA2RHDAC1HDAC6HDAC11 | |
| SCHEMBL5443426 | 0.74 | P2RX4 (0.71) | P2RX4HDAC1HDAC6FOLH1HDAC11 | |
| SCHEMBL12938904 | 0.74 | HDAC6 (0.69) | P2RX4HDAC1HDAC6FOLH1HDAC11 | |
| SCHEMBL7224196 | 0.73 | CDH1 (0.52) | RXFP1KDM4EPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | claimed |
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |