Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | CDH1 | P12830 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224196 | 0.88 | CDH1 (0.52) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL7224206 | 0.84 | DRD2 (0.50) | RXFP1ATMPTGER4CYP1A2CYP2C19 | |
| SCHEMBL7222312 | 0.83 | MEN1 (0.41) | MEN1KMT2ANPC1RAB9ACDH1 | |
| SCHEMBL7218618 | 0.83 | MEN1 (0.42) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL7224007 | 0.80 | EGFR (0.50) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL7224034 | 0.77 | CYP1A2 (0.47) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL11840495 | 0.77 | ALDH1A1 (0.46) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL7217250 | 0.72 | L3MBTL1 (0.49) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2359465 | 0.72 | CYP1A2 (0.68) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL9374216 | 0.70 | ALDH1A1 (0.46) | MEN1KMT2ANPC1RXFP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | claimed |
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |