Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDH1 | P12830 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 4/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218561 | 0.88 | MEN1 (0.47) | CDH1CTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL7217250 | 0.85 | L3MBTL1 (0.49) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL7222312 | 0.83 | MEN1 (0.41) | CDH1CTNNB1TCF7L2MEN1KMT2A | |
| SCHEMBL7218618 | 0.83 | MEN1 (0.42) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL7217219 | 0.81 | L3MBTL1 (0.54) | MEN1KMT2AL3MBTL1PDE8APDE4A | |
| SCHEMBL7224034 | 0.75 | CYP1A2 (0.47) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL11840495 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL7224206 | 0.73 | DRD2 (0.50) | PTGER4KDM4ERXFP1 | |
| SCHEMBL17382572 | 0.70 | ALDH1A1 (0.63) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2359465 | 0.69 | CYP1A2 (0.68) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | claimed |
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |