Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13977074 | 0.87 | KDM4E (0.57) | KDM4EHSD17B10NPC1MAPTRAB9A | |
| SCHEMBL7217219 | 0.86 | L3MBTL1 (0.54) | EGFRKDM4ESRCHSD17B10MEN1 | |
| SCHEMBL9910545 | 0.82 | NPC1 (0.62) | ATMHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7224206 | 0.82 | DRD2 (0.50) | KDM4EATMMAPTHDAC6PTGER4 | |
| SCHEMBL7218561 | 0.80 | MEN1 (0.47) | EGFRKDM4EATMMEN1KMT2A | |
| SCHEMBL9728470 | 0.77 | RAB9A (0.68) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL9728272 | 0.74 | RAB9A (0.56) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7223862 | 0.72 | KDM4E (0.46) | EGFRKDM4ESRCHSD17B10KMT2A | |
| SCHEMBL2724437 | 0.71 | HSD17B10 (0.74) | KDM4EATMHSD17B10KMT2ANPC1 | |
| SCHEMBL9729063 | 0.71 | MAPK1 (0.57) | KDM4EHSD17B10KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | claimed |
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |