Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD40 | P25942 | 2/20 | 0.59 |
| ▸ | CD40LG | P29965 | 2/20 | 0.59 |
| ▸ | FGF1 | P05230 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TIMP3 | P35625 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26695543 | 0.91 | CD40 (0.72) | CD40CD40LGFGF1ALOX5CASP6 | |
| SCHEMBL7224790 | 0.91 | ALOX5 (0.56) | CD40CD40LGFGF1ALOX5CASP6 | |
| SCHEMBL7222842 | 0.89 | ALOX5 (0.68) | CD40CD40LGFGF1ALOX5CASP6 | |
| SCHEMBL7223574 | 0.87 | FGF1 (0.60) | CD40CD40LGFGF1CASP6MEN1 | |
| SCHEMBL7233377 | 0.87 | CASP6 (0.60) | FGF1ALOX5CASP6MEN1KMT2A | |
| SCHEMBL7233109 | 0.86 | FGF1 (0.59) | FGF1CASP6MEN1KMT2AKDR | |
| SCHEMBL7232290 | 0.86 | FGF1 (0.59) | FGF1CASP6MEN1KMT2ATIMP3 | |
| SCHEMBL7230621 | 0.86 | CASP6 (0.60) | CD40CD40LGFGF1CASP6MEN1 | |
| SCHEMBL7231412 | 0.85 | SIRT2 (0.54) | FGF1CASP6MEN1KMT2AMAPT | |
| SCHEMBL6240628 | 0.84 | CASP6 (0.72) | FGF1ALOX5CASP6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | disclosed |