Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 14/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 7/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232072 | 0.92 | HTT (0.48) | S1PR4S1PR5S1PR2S1PR3ALDH1A1 | |
| SCHEMBL7226764 | 0.87 | RAB9A (0.53) | ALDH1A1MAPTNPSR1KDM4ELMNA | |
| SCHEMBL7234200 | 0.87 | GHSR (0.49) | S1PR4S1PR5HTTKMT2ASMN1; SMN2 | |
| SCHEMBL7226254 | 0.85 | NPC1 (0.59) | ALDH1A1MAPTKDM4ELMNAHPGD | |
| SCHEMBL7223170 | 0.84 | NPC1 (0.47) | ALDH1A1MAPTNPSR1KDM4EPOLB | |
| SCHEMBL7234436 | 0.84 | NPC1 (0.45) | ALDH1A1MAPTNPSR1KDM4ELMNA | |
| SCHEMBL7224388 | 0.84 | NPC1 (0.46) | S1PR4ALDH1A1MAPTNPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL7231981 | 0.84 | NPC1 (0.58) | ALDH1A1MAPTKDM4ELMNAHPGD | |
| SCHEMBL7224441 | 0.84 | RAB9A (0.38) | S1PR4S1PR5S1PR2S1PR3ALDH1A1 | |
| SCHEMBL7224839 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPTNPSR1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |