Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 11/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226264 | 0.91 | SLC6A3 (0.33) | CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL7232697 | 0.89 | KDM4C (0.35) | CHRNB2CHRNA4GRM5SLC6A3 | |
| SCHEMBL7231748 | 0.89 | SLC6A4 (0.39) | CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL7226364 | 0.88 | HTR3E (0.35) | CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL7224696 | 0.88 | SLC6A3 (0.40) | CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL7223814 | 0.86 | SLC6A3 (0.33) | CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL7230561 | 0.85 | ITGB2 (0.35) | CHRNB2CHRNA4PTPN11SLC6A4SLC6A3 | |
| SCHEMBL7232162 | 0.84 | HDAC1 (0.50) | CHRNB2CHRNA4HDAC1HDAC6 | |
| SCHEMBL7225781 | 0.84 | PTPN11 (0.44) | GRM5PTPN11SLC6A4SLC6A3 | |
| SCHEMBL7226384 | 0.83 | CHRNB2 (0.34) | CHRNB2CHRNA4SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |