Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225526 | 0.88 | DGAT1 (0.39) | DGAT1CHEK1 | |
| SCHEMBL7225106 | 0.85 | DGAT1 (0.44) | DGAT1SLC6A3HDAC1HDAC6 | |
| SCHEMBL7230609 | 0.84 | DGAT1 (0.38) | DGAT1SLC6A3 | |
| SCHEMBL7225968 | 0.84 | USP30 (0.43) | DGAT1CHEK1 | |
| SCHEMBL7226438 | 0.84 | CTSS (0.36) | DGAT1 | |
| SCHEMBL7224688 | 0.84 | SLC6A3 (0.36) | DGAT1SLC6A3 | |
| SCHEMBL7233275 | 0.83 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL7232544 | 0.83 | DGAT1 (0.44) | DGAT1CHEK1 | |
| SCHEMBL7227071 | 0.83 | HDAC3 (0.44) | ACKR3SLC6A3HDAC3HDAC4HDAC1 | |
| SCHEMBL7226214 | 0.82 | NPC1 (0.38) | SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |