Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227602 | 0.78 | GABRG2 (0.64) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7234152 | 0.76 | GABRA1 (0.60) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7226062 | 0.76 | GABRG2 (0.62) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7232228 | 0.75 | GABRG2 (0.61) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL13130238 | 0.75 | L3MBTL1 (1.00) | L3MBTL1CHRNA7MAPTTP53POLB | |
| SCHEMBL7225665 | 0.74 | GABRA1 (0.58) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7224559 | 0.74 | GABRA1 (0.70) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7231394 | 0.73 | GABRG2 (0.56) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7231846 | 0.73 | GABRG2 (0.56) | GABRG2GABRB3GABRA1GABRA3GABRA5 | |
| SCHEMBL7224413 | 0.72 | GABRA1 (0.67) | GABRG2GABRB3GABRA1GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | claimed |
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | disclosed |