Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 5/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233506 | 0.81 | GABRG2 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7232228 | 0.81 | GABRG2 (0.61) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7234152 | 0.80 | GABRA1 (0.60) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7231394 | 0.79 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7226136 | 0.78 | L3MBTL1 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7225665 | 0.78 | GABRA1 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7224559 | 0.78 | GABRA1 (0.70) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL11009952 | 0.77 | CYP2A6 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7231846 | 0.77 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7224413 | 0.76 | GABRA1 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | claimed |
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | disclosed |