Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.57 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.57 |
| ▸ | KYNU | Q16719 | 1/20 | 0.57 |
| ▸ | TLR2 | O60603 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.55 |
| ▸ | CPB1 | P15086 | 1/20 | 0.55 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840311 | 1.00 | SIRT2 (0.61) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| SCHEMBL1840309 | 1.00 | SIRT2 (0.61) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL3952159 | 0.99 | SIRT2 (0.60) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL3952162 | 0.99 | SIRT2 (0.60) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL6528872 | 0.99 | SIRT2 (0.60) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| SCHEMBL8447229 | 0.96 | SIRT2 (0.59) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| SCHEMBL8447232 | 0.96 | SIRT2 (0.59) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL6236103 | 0.95 | SIRT2 (0.58) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL6236109 | 0.95 | SIRT2 (0.58) | SIRT2SIRT1SIRT3ITGB3ITGA2B | |
| SCHEMBL8386880 | 0.93 | SIRT2 (0.67) | SIRT2SIRT1SIRT3KYNUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894185-B2 | Substituted chiral allosteric hemoglobin modifiers | Allós Therapeutics, Inc. (US) | 2005-05-17 | — | — | US | disclosed |
| EP-1206442-A4 | SUBSTITUTED CHIRAL ALLOSTERIC HEMOGLOBIN MODIFIERS | UNIV VIRGINIA COMMONWEALTH (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20030130523-A1 | Substituted chiral allosteric hemoglobin modifiers | ABRAHAM DONALD J (US) | 2003-07-10 | — | — | US | disclosed |
| US-6486342-B1 | Substituted chiral allosteric hemoglobin modifiers | VIRGINIA COMMONWEALTH UNIVERSITY | 2002-11-26 | — | — | US | disclosed |
| EP-1206442-A1 | SUBSTITUTED CHIRAL ALLOSTERIC HEMOGLOBIN MODIFIERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001014316-A1 | SUBSTITUTED CHIRAL ALLOSTERIC HEMOGLOBIN MODIFIERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130523-A1 | Substituted chiral allosteric hemoglobin modifiers | HBZ, HBB, HBG2 | SIRT2 4403/4885SIRT1 4014/4885SIRT3 4226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.