Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 8/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246555 | 0.92 | GABRA5 (0.60) | GABRA5CHRNB2CHRNA7CHRNA4LMNA | |
| SCHEMBL6030328 | 0.90 | GABRA5 (0.53) | GABRA5MAPTRAB9ACHRNB2CHRNA7 | |
| SCHEMBL7230242 | 0.86 | MAPT (0.56) | GABRA5MAPTCXCR2SMPD1 | |
| SCHEMBL1462223 | 0.84 | GABRA5 (0.61) | GABRA5MAPTRAB9ALMNACXCR2 | |
| SCHEMBL1255787 | 0.84 | NPC1 (0.55) | GABRA5MAPTRAB9ANPC1LMNA | |
| SCHEMBL27395439 | 0.81 | RAB9A (0.68) | MAPTRAB9ANPC1LMNA | |
| SCHEMBL6339006 | 0.80 | OPRM1 (0.57) | MAPTRAB9ANPC1LMNA | |
| SCHEMBL20830743 | 0.79 | CHRNB2 (0.61) | MAPTRAB9ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL1462208 | 0.79 | GABRA5 (0.60) | GABRA5LMNA | |
| SCHEMBL7229900 | 0.79 | ALOX5 (0.56) | GABRA5CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586475-B1 | 5-chloro-N-(2-N,N-diethylamino)ethyl)-2- methoxy-4-(1-naphthoylamino)benzamide and prodrugs, used for prevention of neurodegenarative diseases such as Alzheimer's disease | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-07-01 | — | — | US | disclosed |
| EP-1132376-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |