Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.33 |
| ▸ | RPS27 | P42677 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NMT2 | O60551 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227853 | 0.83 | SCN8A (0.35) | KDM4ESCN8ASMN1; SMN2NMT2NMT1 | |
| SCHEMBL7222760 | 0.82 | KDM4E (0.36) | KDM4EALDH1A1GAAMAPK1L3MBTL1 | |
| SCHEMBL7222807 | 0.79 | SCN8A (0.36) | KDM4EALDH1A1GAAL3MBTL1SCN8A | |
| SCHEMBL6746830 | 0.76 | ACHE (0.39) | SCN8A | |
| SCHEMBL6748820 | 0.70 | DPP7 (0.36) | KDM4EGAASCN8ASMN1; SMN2 | |
| SCHEMBL7223365 | 0.66 | P2RX7 (0.38) | RXFP1NPSR1SMN1; SMN2HTT | |
| SCHEMBL7220663 | 0.63 | OPRM1 (0.35) | — | |
| SCHEMBL6749822 | 0.63 | KDM1A (0.49) | KDM4EALDH1A1SCN8ANPSR1SMN1; SMN2 | |
| SCHEMBL6749836 | 0.62 | ACHE (0.44) | SCN8A | |
| SCHEMBL6744792 | 0.61 | TK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583138-B1 | Mediators or antagonists of the effects of histamine, leukotriene and the like; heterocyclic ring condensed benzothiazine compounds; inhibit the activation of the tyrosine kinase of 72 kDa | EISAI CO., LTD. (JP) | 2003-06-24 | — | — | US | claimed |
| EP-1057830-A1 | HETEROCYCLE-FUSED BENZOTHIAZINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-12-06 | — | — | EP | claimed |