Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223363 | 0.82 | TP53 (0.33) | KMT2ATSHRMEN1CYP1A2CYP2D6 | |
| SCHEMBL7220663 | 0.78 | OPRM1 (0.35) | KMT2AMEN1CYP2D6 | |
| SCHEMBL6751602 | 0.72 | CA12 (0.43) | KMT2ATSHRMEN1CYP2D6TP53 | |
| SCHEMBL6746830 | 0.71 | ACHE (0.39) | KMT2AMEN1 | |
| SCHEMBL7227853 | 0.69 | SCN8A (0.35) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6746814 | 0.66 | — | — | |
| SCHEMBL7229042 | 0.66 | KDM4E (0.35) | HTTNPSR1SMN1; SMN2RXFP1 | |
| SCHEMBL6746847 | 0.62 | HTR2A (0.41) | — | |
| SCHEMBL8342160 | 0.62 | ALDH1A1 (0.42) | TSHRNPSR1SMN1; SMN2 | |
| SCHEMBL8444354 | 0.61 | LMNA (0.58) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583138-B1 | Mediators or antagonists of the effects of histamine, leukotriene and the like; heterocyclic ring condensed benzothiazine compounds; inhibit the activation of the tyrosine kinase of 72 kDa | EISAI CO., LTD. (JP) | 2003-06-24 | — | — | US | claimed |