Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CDK8 | P49336 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.51 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367399 | 0.79 | MAPT (0.51) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL10369493 | 0.79 | LTK (0.40) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL7224408 | 0.73 | GPR3 (0.54) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL1159880 | 0.72 | LTK (0.72) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL9001235 | 0.71 | NOTUM (0.50) | KMT2ANOTUMHPGDLMNAKDM4E | |
| SCHEMBL7229902 | 0.69 | LTK (0.68) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL2920391 | 0.68 | LTK (1.00) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL10368213 | 0.68 | MAPT (0.49) | LTKPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL10443136 | 0.67 | MAOA (0.52) | KMT2ANOTUMCHEK1HPGDMEN1 | |
| SCHEMBL9834123 | 0.67 | CES1 (0.57) | LTKPLK4DAPK3PIM1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6538009-B2 | Selective cyclooxygenase-2 (COX-2) inhibitors; for example, 1-(5-Methanesulfonyl-pyridin-2-yl)-7-methoxy-3-trifluoromethyl-4,5-dihydro -1H-benzo(g) indazole | PFIZER, INC. | 2003-03-25 | — | — | US | disclosed |
| US-20020115856-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | SAKYA SUBAS MAN (US) | 2002-08-22 | — | — | US | disclosed |
| EP-1142889-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020115856-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | FPR3, P2RX3, FPR1 | LTK 1604/4885PLK4 3904/4885DAPK3 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.