Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 14/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2626789 | 0.98 | EGFR (0.46) | EGFRMEN1NPC1PABPC1KMT2A | |
| Iodide SCHEMBL30367691 | 0.96 | EGFR (0.44) | EGFRMEN1NPC1PABPC1KMT2A | |
| Hydrochloric Acid SCHEMBL333986 | 0.90 | KDM4E (0.39) | EGFRMEN1NPC1PABPC1KMT2A | |
| SCHEMBL2626784 | 0.88 | EGFR (0.39) | EGFRMEN1NPC1PABPC1KMT2A | |
| Hydrochloric Acid SCHEMBL41927 | 0.87 | TERT (0.43) | EGFRMEN1NPC1PABPC1KMT2A | |
| Hydrochloric Acid SCHEMBL30898816 | 0.87 | TERT (0.43) | EGFRMEN1NPC1PABPC1KMT2A | |
| SCHEMBL2626785 | 0.85 | TERT (0.44) | EGFRMEN1NPC1PABPC1KMT2A | |
| SCHEMBL12312493 | 0.85 | TERT (0.44) | EGFRMEN1NPC1PABPC1KMT2A | |
| Iodide SCHEMBL30367122 | 0.84 | TERT (0.43) | EGFRMEN1NPC1PABPC1KMT2A | |
| SCHEMBL13097886 | 0.82 | APAF1 (0.40) | EGFRMEN1NPC1PABPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6570019-B2 | Hair dyes; uniformity, stability | WELLA AG (DE) | 2003-05-27 | — | — | US | disclosed |
| US-4338180-A | SURFACE-CHALCOGENATED MOLYBENUM OR TUNGSTEN; SOLAR CELLS | KURARAY CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |