Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7224287 | 0.99 | NPC1 (0.62) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7223170 | 0.87 | NPC1 (0.47) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7225714 | 0.87 | PDE7A (0.50) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7234830 | 0.84 | RAB9A (0.42) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7230181 | 0.83 | FAAH (0.47) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7072612 | 0.83 | RAB9A (0.49) | NPC1RAB9AALDH1A1KMT2AMAPT | |
| SCHEMBL7226764 | 0.83 | RAB9A (0.53) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7231145 | 0.83 | SLC9A1 (0.44) | NPC1RAB9ALMNASMN1; SMN2GAA | |
| SCHEMBL7225840 | 0.83 | RAB9A (0.41) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7233102 | 0.83 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |