Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347522 | 0.80 | TSHR (0.37) | NAPRTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL19938127 | 0.78 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7237319 | 0.77 | CES2 (0.38) | ALDH1A1LMNASMN1; SMN2TP53NPC1 | |
| SCHEMBL29177284 | 0.77 | CES2 (0.38) | ALDH1A1LMNAKMT2AMEN1NPSR1 | |
| SCHEMBL7338642 | 0.77 | CES2 (0.38) | LMNASMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL8215216 | 0.75 | MAPT (0.48) | HSD17B10ALDH1A1LMNACYP2C19SMN1; SMN2 | |
| SCHEMBL8954661 | 0.75 | MAPT (0.32) | — | |
| SCHEMBL8459393 | 0.75 | HPGD (0.50) | NAPRTHSD17B10ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8384037 | 0.74 | PLK1 (0.40) | HSD17B10ALDH1A1LMNACYP1A2SMN1; SMN2 | |
| SCHEMBL28971992 | 0.74 | MAPT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503917-B1 | Post-menopause, atherosclerosis, osteoporosis, and Alzheimer*s disease treatment | WYETH, FIVE GIRALDA FARMS | 2003-01-07 | — | — | US | disclosed |
| US-6384058-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |
| US-6384060-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |
| US-6384057-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |