Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232713 | 0.88 | HDAC1 (0.48) | NPC1RAB9ACNR1MEN1KMT2A | |
| SCHEMBL7231985 | 0.86 | HDAC1 (0.46) | NPC1RAB9ACNR1L3MBTL1SLC6A3 | |
| SCHEMBL7232162 | 0.84 | HDAC1 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2HDAC1 | |
| SCHEMBL7231176 | 0.84 | CA12 (0.39) | SLC6A3SLC6A4HDAC1HDAC6 | |
| SCHEMBL7230828 | 0.83 | SLC6A3 (0.41) | NPC1RAB9ACNR1MEN1ALDH1A1 | |
| SCHEMBL7232072 | 0.83 | HTT (0.48) | NPC1RAB9AMEN1ALDH1A1HPGD | |
| SCHEMBL7233040 | 0.82 | ACKR3 (0.53) | ACKR3 | |
| SCHEMBL7231983 | 0.82 | SLC6A3 (0.37) | NPC1RAB9ACNR1MEN1ALDH1A1 | |
| SCHEMBL7230561 | 0.82 | ITGB2 (0.35) | CNR1MEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7225689 | 0.81 | FAAH (0.43) | NPC1RAB9AMEN1KMT2AACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |