Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225396 | 0.89 | SLC6A4 (0.37) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL7234091 | 0.87 | SLC6A4 (0.41) | SLC6A3SLC6A4ALDH1A1KMT2ASLC6A2 | |
| SCHEMBL7223564 | 0.85 | SLC6A4 (0.39) | SLC6A3SLC6A4ALDH1A1SLC6A2CHRNB2 | |
| SCHEMBL7232046 | 0.85 | ALDH1A1 (0.39) | SLC6A3SLC6A4ALDH1A1SLC6A2CHRNA1 | |
| SCHEMBL7231538 | 0.84 | SLC6A3 (0.42) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL7231938 | 0.83 | MAPK14 (0.40) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7230650 | 0.82 | NPC1 (0.41) | SLC6A3SLC6A4HPGDALDH1A1KMT2A | |
| SCHEMBL7224405 | 0.81 | SLC6A3 (0.36) | SLC6A3SLC6A4HPGDSLC6A2CHRNA1 | |
| SCHEMBL7233162 | 0.81 | HTR3E (0.38) | SLC6A3SLC6A4SLC6A2CNR1NPC1 | |
| SCHEMBL7225309 | 0.80 | PDE4A (0.35) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |