SCHEMBL7231950

SCHEMBL7231950

O=C(N[C@@H]1C[C@H]2CC[C@@H]1N2)c1ccc(Sc2ccc(F)c(Cl)c2)s1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
TAS1R2 Q8TE23 1/20 0.36
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32
F10 P00742 1/20 0.32
SLC6A3 Q01959 6/20 0.32
SLC6A4 P31645 5/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
DHODH Q02127 1/20 0.31
SLC6A2 P23975 3/20 0.31
CHRNA7 P36544 3/20 0.31
CHRNA1 P02708 2/20 0.31
CHRNG P07510 2/20 0.31
ITGA5 P08648 2/20 0.31
CHRNB1 P11230 2/20 0.31
CHRNB2 P17787 2/20 0.31
CHRNB4 P30926 2/20 0.31
CHRNA3 P32297 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7232598 0.91 SLC6A3 (0.39) TAS1R3TAS1R2KMT2ASLC6A3SLC6A4
SCHEMBL7234021 0.88 SLC6A3 (0.39) MEN1ALDH1A1KMT2ASLC6A3SLC6A4
Hydrochloric Acid SCHEMBL7231366 0.87 SLC6A3 (0.38) MEN1ALDH1A1KMT2ASLC6A3SLC6A4
SCHEMBL7226168 0.87 HSD17B1 (0.37) F10SLC6A3SLC6A4L3MBTL1
SCHEMBL7233118 0.85 CHRNB2 (0.39) MEN1ALDH1A1KMT2ASLC6A3SLC6A4
SCHEMBL7231963 0.84 ESR1 (0.37) ALDH1A1SLC6A3SLC6A4SLC6A2CHRNA7
SCHEMBL7224100 0.84 USP7 (0.33) F10SLC6A3SLC6A4CHRNB4CHRNA3
SCHEMBL7224957 0.83 TAS1R3 (0.36) TAS1R3TAS1R1TAS1R2MEN1ALDH1A1
SCHEMBL7231860 0.82 HSD17B1 (0.48) SLC6A3SLC6A4L3MBTL1SLC6A2CHRNA7
SCHEMBL7224358 0.82 SLC6A3 (0.36) SLC6A3SLC6A4SLC6A2CHRNA7CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6562816-B2 Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects PHARMACIA & UPJOHN COMPANY 2003-05-13 US claimed
US-6562816-B2 Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects PHARMACIA & UPJOHN COMPANY 2003-05-13 US disclosed