Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.47 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.47 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28866741 | 0.80 | ALDH1A1 (0.49) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL57836 | 0.77 | TSHR (0.40) | TDP1TSHRALDH1A1CYP3A4ALOX15 | |
| SCHEMBL7615798 | 0.75 | TDP1 (0.40) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL221622 | 0.75 | TDP1 (0.56) | TDP1TSHRALDH1A1CYP3A4GPR35 | |
| SCHEMBL3036771 | 0.75 | GPR35 (0.56) | TDP1ALDH1A1CYP3A4ALOX15HPGD | |
| SCHEMBL19859 | 0.73 | VCAM1 (0.46) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL1460867 | 0.72 | TDP1 (0.61) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL9452603 | 0.72 | TSHR (0.59) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL29259432 | 0.72 | VCAM1 (0.36) | VCAM1TDP1TSHRALDH1A1CYP3A4 | |
| SCHEMBL27817013 | 0.72 | VCAM1 (0.44) | VCAM1TDP1TSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112694473-A | 7, 9-disubstituted berberine derivative and preparation method and application thereof | 南京林业大学 | 2021-04-23 | — | — | CN | claimed |
| EP-0464736-B1 | A process for producing 5-amino-4-halogeno-1H-pyrazole compounds | FUJI PHOTO FILM CO LTD (JP) | 1997-01-02 | — | — | EP | claimed |
| US-5122612-A | PROCESS FOR PRODUCING 5-AMINO-4-HALOGENO-1H-PYRAZOLE COMPOUNDS | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-16 | — | — | US | claimed |
| EP-0464736-A1 | A process for producing 5-amino-4-halogeno-1H-pyrazole compounds | Fuji Photo Film Co., Ltd. (JP) | 1992-01-08 | — | — | EP | claimed |
| CN-112694473-B | 7, 9-disubstituted berberine structural analogue and preparation method and application thereof | 南京林业大学 | 2022-09-20 | — | — | CN | disclosed |
| CN-112694473-A | 7, 9-disubstituted berberine derivative and preparation method and application thereof | 南京林业大学 | 2021-04-23 | — | — | CN | disclosed |
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
| EP-0464736-B1 | A process for producing 5-amino-4-halogeno-1H-pyrazole compounds | FUJI PHOTO FILM CO LTD (JP) | 1997-01-02 | — | — | EP | disclosed |
| US-5122612-A | PROCESS FOR PRODUCING 5-AMINO-4-HALOGENO-1H-PYRAZOLE COMPOUNDS | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-16 | — | — | US | disclosed |
| EP-0464736-A1 | A process for producing 5-amino-4-halogeno-1H-pyrazole compounds | Fuji Photo Film Co., Ltd. (JP) | 1992-01-08 | — | — | EP | disclosed |
| EP-0051818-B1 | PROCESS FOR THE PRODUCTION OF DISCHARGE-RESIST PRINTS ON TEXTILE MATERIALS | CASSELLA Aktiengesellschaft (DE) | 1985-09-04 | — | — | EP | disclosed |
| US-4398913-A | ALKALINE PASTES | CASSELLA AKTIENGESELLSCHAFT (DE) | 1983-08-16 | — | — | US | disclosed |
| EP-0051818-A1 | Process for the production of discharge-resist prints on textile materials | CASSELLA Aktiengesellschaft (DE) | 1982-05-19 | — | — | EP | disclosed |