Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672066 | 0.91 | ALDH1A1 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL18511376 | 0.91 | ALDH1A1 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL4674867 | 0.85 | TAAR1 (0.54) | DPP4DPP7DPP8DPP9TAAR1 | |
| SCHEMBL7216586 | 0.85 | TAAR1 (0.54) | DPP4DPP7DPP8DPP9TAAR1 | |
| SCHEMBL7244017 | 0.79 | ALDH1A1 (0.47) | DPP4DPP8DPP9FAPALDH1A1 | |
| SCHEMBL44127 | 0.77 | PKM (0.58) | DPP4DPP8DPP9FAPALDH1A1 | |
| SCHEMBL29401250 | 0.77 | PKM (0.58) | DPP4DPP8DPP9FAPALDH1A1 | |
| SCHEMBL44126 | 0.77 | PKM (0.58) | DPP4DPP8DPP9FAPALDH1A1 | |
| SCHEMBL268942 | 0.77 | PKM (0.58) | DPP4DPP8DPP9FAPALDH1A1 | |
| Carbamic Acid SCHEMBL28108559 | 0.76 | DPP4 (0.48) | DPP4DPP7DPP8DPP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | AMGEN INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | DPYD, IL6, IL1B | DPP4 301/4885DPP7 378/4885DPP8 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.