Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7239400 | 1.00 | ALOX15 (0.54) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7239286 | 0.81 | ALOX15 (0.58) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7239277 | 0.81 | ALOX15 (0.58) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2203941 | 0.81 | TERT (0.49) | ALOX15ALDH1A1SMN1; SMN2F2PLG | |
| SCHEMBL828067 | 0.81 | ALOX15 (0.71) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2203937 | 0.81 | TERT (0.49) | ALOX15ALDH1A1SMN1; SMN2F2PLG | |
| SCHEMBL1696434 | 0.79 | ALOX15 (0.59) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6870647 | 0.78 | F2 (0.40) | ALDH1A1SMN1; SMN2LMNAF2PLG | |
| SCHEMBL6870650 | 0.78 | F2 (0.40) | ALDH1A1SMN1; SMN2LMNAF2PLG | |
| SCHEMBL6870651 | 0.78 | F2 (0.40) | ALDH1A1SMN1; SMN2LMNAF2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660764-B2 | Telomerase inhibitors such as trans-3-(benzothien-6-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide; use as antitumor agent | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-12-09 | — | — | US | disclosed |
| US-20020123509-A1 | Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-09-05 | — | — | US | disclosed |
| WO-2002051830-A1 | CARBOXAMIDES FOR USE AS TELOMERASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123509-A1 | Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof | ASS1, ADCY1, ADCY3 | ALOX15 1669/4885HTT 3942/4885PLK1 3897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.