Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237312 | 0.78 | POLB (0.30) | L3MBTL1POLB | |
| SCHEMBL6787059 | 0.70 | MMP13 (0.42) | MAPK1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7239714 | 0.68 | PROKR1 (0.41) | LMNAL3MBTL1POLBTSHRKMT2A | |
| SCHEMBL880086 | 0.68 | L3MBTL1 (0.46) | MAPK1LMNAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL6786967 | 0.67 | HDAC1 (0.37) | L3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6433710 | 0.67 | L3MBTL1 (0.51) | MAPK1LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL4611345 | 0.67 | CA12 (0.35) | LMNAKMT2A | |
| SCHEMBL2077067 | 0.66 | USP2 (0.59) | MAPK1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2080828 | 0.64 | POLB (0.51) | MAPK1LMNAALDH1A1POLBKMT2A | |
| SCHEMBL7270758 | 0.64 | ALDH1A1 (0.42) | LMNASMN1; SMN2L3MBTL1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506764-B1 | B-X-(CH2)m-CR1R2-(CH2)n-CO-Y (I) have therapeutic utility as inhibitors of metalloproteinases etc. for medicine by human articular cartilage cells and also involved in the destruction of myelin basic protein, a phenomenon associated with | DARWIN DISCOVERY, LTD. (GB) | 2003-01-14 | — | — | US | disclosed |