Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.51 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240891 | 0.90 | POLB (0.52) | TK1POLB | |
| Phosphoric Acid SCHEMBL7240883 | 0.86 | TYMP (0.43) | TK1 | |
| Phosphoric Acid SCHEMBL7243142 | 0.86 | TYMP (0.43) | TK1 | |
| SCHEMBL26125047 | 0.85 | TK1 (0.48) | TK1TYMSPOLB | |
| SCHEMBL13253917 | 0.83 | ALDH1A1 (0.42) | TK1 | |
| SCHEMBL16187026 | 0.83 | TK1 (0.44) | TK1POLB | |
| SCHEMBL135210 | 0.83 | TK1 (0.44) | TK1POLB | |
| SCHEMBL17515060 | 0.82 | TK1 (0.51) | TK1TYMSPOLB | |
| SCHEMBL548543 | 0.81 | TYMS (0.52) | TK1TYMSPOLB | |
| SCHEMBL3092317 | 0.79 | TK1 (0.52) | TK1TYMSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531476-B1 | Block multiplication of virus within body and restore immune functions by virtue of inhibitory activity toward platelet activating factor | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1095029-B1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIV PARIS 7 DENIS DIDEROT (FR) | 2002-09-18 | — | — | EP | disclosed |
| EP-1095029-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - Denis DIDEROT (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001677-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2000-01-13 | — | — | WO | disclosed |