Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.52 |
| ▸ | POLD1 | P28340 | 1/20 | 0.52 |
| ▸ | P2RY2 | P41231 | 5/20 | 0.45 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 5/20 | 0.44 |
| ▸ | DTYMK | P23919 | 2/20 | 0.43 |
| ▸ | TK1 | P04183 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243147 | 0.90 | TK1 (0.51) | POLBTK1 | |
| SCHEMBL29538414 | 0.88 | POLB (0.51) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL3715513 | 0.88 | POLB (0.51) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL29723202 | 0.88 | POLB (0.51) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL31742537 | 0.87 | POLB (0.51) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL5191085 | 0.86 | POLB (0.50) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL5285301 | 0.84 | POLB (0.48) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL15515984 | 0.84 | POLB (0.56) | POLBPOLA1POLD1P2RY2P2RY4 | |
| SCHEMBL8441087 | 0.84 | P2RY6 (0.59) | POLA1P2RY2P2RY4P2RY6 | |
| SCHEMBL5409945 | 0.83 | POLB (0.51) | POLBPOLA1POLD1P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531476-B1 | Block multiplication of virus within body and restore immune functions by virtue of inhibitory activity toward platelet activating factor | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1095029-B1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIV PARIS 7 DENIS DIDEROT (FR) | 2002-09-18 | — | — | EP | disclosed |
| EP-1095029-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - Denis DIDEROT (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001677-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2000-01-13 | — | — | WO | disclosed |