SCHEMBL724150

SCHEMBL724150

O=C(c1ccc(F)cc1)c1c[nH]c(-c2ccccc2C(F)(F)F)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
PARP1 P09874 1/20 0.40
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 2/20 0.39
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
KMO O15229 2/20 0.37
USP1 O94782 1/20 0.37
WDR48 Q8TAF3 1/20 0.37
ACP1 P24666 1/20 0.36
SCN9A Q15858 1/20 0.35
GRM5 P41594 1/20 0.35
CNR2 P34972 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL724793 0.79 HTT (0.41) KMT2AMEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29986685 0.78 TUBB4A (0.45) CYP1A2CYP3A4CYP2C19ALDH1A1TRPA1
SCHEMBL771734 0.78 TUBB4A (0.45) CYP1A2CYP3A4CYP2C19ALDH1A1TRPA1
SCHEMBL6332899 0.77 P2RX7 (0.46) HDAC3HDAC7HDAC10HDAC6PARP1
SCHEMBL20077790 0.74 KDM4E (0.46) PARP1CYP1A2CYP2C19ALDH1A1HPGD
SCHEMBL724434 0.71 ALDH1A1 (0.42) KMT2AMEN1CYP1A2ALDH1A1HPGD
SCHEMBL723473 0.71 CHEK2 (0.41) KMT2AMEN1ALDH1A1SCN9ACNR2
SCHEMBL8797355 0.70 HSD11B1 (0.41) HDAC3HDAC7HDAC10HDAC6PARP1
Hydrochloric Acid SCHEMBL724182 0.70 ALDH1A1 (0.41) KMT2AMEN1ALDH1A1HPGDNPC1
SCHEMBL724617 0.69 HSD11B1 (0.38) KMT2AALDH1A1HPGDKMONR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188072-A1 COMPOUNDS FOR TREATMENT OF CANCER UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-06-12 US disclosed
US-12187720-B2 Compounds for treatment of cancer UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2025-01-07 US disclosed
US-11465987-B2 Compounds for treatment of cancer Oncternal Therapeutics, Inc. (US) 2022-10-11 US disclosed
US-20220024912-A1 COMPOUNDS FOR TREATMENT OF CANCER Oncternal Therapeutics, Inc. (US) 2022-01-27 US disclosed
US-11084811-B2 Compounds for treatment of cancer Oncternal Therapeutics, Inc. (US) 2021-08-10 US disclosed
EP-3793548-A1 COMPOUNDS FOR TREATMENT OF PANCREATIC CANCER University of Tennessee Research Foundation (US) 2021-03-24 EP disclosed
EP-2608671-B1 COMPOUNDS FOR TREATMENT OF CANCER GTX INC (US) 2018-12-12 EP disclosed
US-20170226086-A1 COMPOUNDS FOR TREATMENT OF CANCER GTx. Inc. (US) 2017-08-10 US disclosed
US-9447049-B2 Compounds for treatment of cancer UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2016-09-20 US disclosed
EP-3064204-A1 COMPOUNDS FOR TREATMENT OF CANCER GTx, Inc. (US) 2016-09-07 EP disclosed
US-9334242-B2 Compounds for treatment of cancer GTX, INC. (US) 2016-05-10 US disclosed
US-8822513-B2 Compounds for treatment of cancer GTX, INC. (US) 2014-09-02 US disclosed
WO-2012027481-A9 COMPOUNDS FOR TREATMENT OF CANCER GTX, INC. (US) 2013-10-10 WO disclosed
US-20130197049-A1 COMPOUNDS FOR TREATMENT OF CANCER UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-08-01 US disclosed
EP-2608671-A1 COMPOUNDS FOR TREATMENT OF CANCER Gtx, Inc. (US) 2013-07-03 EP disclosed
EP-2542081-A1 COMPOUNDS FOR TREATMENT OF CANCER Gtx, Inc. (US) 2013-01-09 EP disclosed
US-20120071524-A1 COMPOUNDS FOR TREATMENT OF CANCER ONCTERNAL THERAPEUTICS, INC 2012-03-22 US disclosed
WO-2012027481-A1 COMPOUNDS FOR TREATMENT OF CANCER GTX, INC. (US) 2012-03-01 WO disclosed
US-20110257196-A1 COMPOUNDS FOR TREATMENT OF CANCER ONCTERNAL THERAPEUTICS, INC 2011-10-20 US disclosed
WO-2011109059-A1 COMPOUNDS FOR TREATMENT OF CANCER GTX, INC. (US) 2011-09-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12187720-B2 Compounds for treatment of cancer KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20120071524-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20130197049-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-11084811-B2 Compounds for treatment of cancer KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20220024912-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20170226086-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20110257196-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-20250188072-A1 COMPOUNDS FOR TREATMENT OF CANCER KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885
US-11465987-B2 Compounds for treatment of cancer KLK3, BRDT, ACP3 HDAC3 39/4885HDAC7 29/4885HDAC10 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.