Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128643 | 0.83 | TRPV6 (0.35) | KDM4EALDH1A1MEN1MAPTHTT | |
| SCHEMBL7117376 | 0.83 | ALDH1A1 (0.34) | BAZ2AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL5401530 | 0.83 | MCL1 (0.40) | KDM4EALDH1A1MEN1MAPTHTT | |
| SCHEMBL6092642 | 0.82 | ALOX15 (0.42) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7125283 | 0.81 | PDGFRB (0.34) | KDM4EALDH1A1MEN1MAPTHTT | |
| SCHEMBL6091353 | 0.81 | ALOX15 (0.45) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7593513 | 0.80 | LMNA (0.36) | BAZ2AALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL6089632 | 0.78 | HSD17B10 (0.44) | BAZ2AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL7117883 | 0.78 | HRH3 (0.42) | BAZ2AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL7118384 | 0.78 | PDE5A (0.37) | KDM4EALDH1A1MEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | disclosed |
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |