Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | EIF4E | P06730 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2957169 | 0.88 | NPC1 (0.70) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL30785680 | 0.88 | NPC1 (0.70) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL28060965 | 0.78 | ENPP2 (0.85) | ENPP2MAOB | |
| SCHEMBL27292647 | 0.78 | RAB9A (0.60) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL28019722 | 0.77 | NPC1 (0.56) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL3491442 | 0.77 | NPC1 (0.58) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL2961408 | 0.75 | ALDH1A1 (0.65) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL227679 | 0.75 | PTGS2 (0.58) | NPC1RAB9ACASP3SENP7EIF4E | |
| SCHEMBL5140 | 0.75 | ENPP2 (1.00) | NPC1RAB9AENPP2ALDH1A1 | |
| SCHEMBL7344145 | 0.75 | ENPP2 (1.00) | NPC1RAB9AENPP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534506-B2 | For therapy of cancer, neurofibromin benign proliferative disorder; blindness related to retinal vascularization; infections from hepatitis delta and related viruses; prophylaxis of restenosis; polycystic kidney disease | MERCK & CO., INC. | 2003-03-18 | — | — | US | disclosed |
| US-20020123497-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123497-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | NPC1 197/4885RAB9A 430/4885CASP3 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.